Table 1.
Characteristics and outcomes of patients with mucosal leishmaniasis treated with liposomal amphotericin B*
Sex/age, years | Lesion site | Previous treatment | Contraindication(s)† | Total cumulative dose, mg | Weight, Kg | Dose mg/Kg | Outcome | Duration of hospital stay/follow-up |
---|---|---|---|---|---|---|---|---|
1 M/64 | Nasal septum | None | AVR | 2100 | 65 | 32.3 | Cure | 15 days/8 months |
2 M/40 | Nasal septum | None | AVR | 2910 | 100 | 29.1 | Cure | 15 days/9 months |
3 M/84 | Nasal septum | None | AVR, CRF | 2000 | 70 | 28.6 | Cure | 23 days/40 months |
4 M/76 | Nasal septum | (2 years earlier) | AVR, ARF | 3000 | 60 | 50 | Cure | 21 days/37 months |
5 M/47 | Palate, larynx | (3 years earlier) | AVR, DM | 3000 | 60 | 50 | Cure | 40 days/35 months |
6 M/66 | Nasal septum | (9 days earlier) | ARF | 2600 | 68 | 38.2 | Cure | 24 days/25 months |
7 M/35 | Nasal septum, palate | (10 days earlier) | AVR | 2250 | 85 | 26.5 | Cure | 21 days/40 months |
8 M/52 | Nasal septum, palate | (5 days earlier) | ARF | 2240 | 93 | 24 | Cure | 14 days/7 months |
Mean | 25,125 | 75,125 | 34.83 | 21,625 days/25,125 months |
ARF = acute renal failure; AVR = altered ventricular repolarization; CRF = chronic renal failure; DM = diabetes mellitus.
Contraindications to the use of antimonials, pentamidine, or deoxycholate amphotericin B.