Table 2.
Baseline characteristics of imported histoplasmosis in 104 HIV-infected patients, France*
| Characteristic | Pre-HAART (1985–1994), n = 40 | HAART (1997–2006), n = 64 | P |
|---|---|---|---|
| Clinical presentation | |||
| Time between onset of symptoms and diagnosis (days) | 59 (66) | 65 (65) | 0.66 |
| Fever, no. (%) | 35 (88) | 54 (84) | 0.78 |
| Adenopathy, no. (%) | 21 (49) | 40 (63) | 0.17 |
| Hepatomegaly, no. (%) | 19 (48) | 27 (43) | 0.56 |
| Splenomegaly, no. (%) | 14 (36) | 28 (44) | 0.39 |
| Pulmonary symptoms, no. (%) | 24 (60) | 22 (34) | 0.01 |
| Cough | 23 (58) | 17 (27) | 0.002 |
| Sputum | 12 (30) | 2 (3) | < 10−3 |
| Dyspnea | 11 (28) | 13 (20) | 0.40 |
| Abnormal chest radiograph | 25 (61) | 33 (52) | 0.34 |
| Mucocutaneous symptoms, no. (%) | 23 (56) | 28 (44) | 0.17 |
| Papule | 15 (37) | 11 (17) | 0.02 |
| Oral ulceration | 6 (15) | 4 (6) | 0.18 |
| Skin ulceration | 3 (8) | 2 (3) | 0.37 |
| Abdominal symptoms, no. (%) | 16 (40) | 23 (36) | 0.68 |
| Neurologic symptoms, no. (%) | 6 (15) | 7 (11) | 0.56 |
| Biologic parameters, no. (%) | |||
| Hemoglobin (g/dL) | 9.1 (2.2) | 8.3 (1.9) | 0.07 |
| Leukocytes (109/L) | 2.9 (1.2) | 3.5 (4.4) | 0.37 |
| Platelets (109/L) | 188 (104) | 147 (150) | 0.14 |
| AST (N× upper reference value) | 2.1 (2.1) | 3.9 (4.5) | 0.04 |
| ALP (N× upper reference value) | 3.9 (7.1) | 1.8 (1.2) | 0.03 |
*
HIV = human immunodeficiency virus; HAART = highly active antiretroviral therapy; AST = aspartate aminotransferase; ALP = alkaline phosphatase.