Table 5.
Comparison of AIDS-related histoplasmosis cases from disease-endemic areas with 104 cases from France, a non-endemic area*
| Area | Period | No. | Age, years | Men, % | CD4 cell count/μL | HAART, % | AIDS defining, % | Clinical features, % | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fever | Adp | HM, SM | Skin | Pulm | Abdo | Neuro | ||||||||
| Indiana, USA | 1981–1989 | 72 | NA | NA | NA | 0 | 69 | 96 | 17 | 26, 13 | 1 | 53 | 3 | 18 |
| United States | 1996–1999 | 92 | 39 | 89 | 25 | 35 | > 50 | 88 | NA | NA | NA | 55 | 33 | 16 |
| Colombia | 1979–2001 | 30 | 36 | 97 | 45 | 37 | ND | 90 | 57 | 13 | 53 | 80 | 47 | NA |
| Panama | 1997–2003 | 104 | 37 | 85 | 65 | 11 | 68 | 92 | 19 | 42 | 17 | 64 | 50 | NA |
| French Guiana | 1982–2007 | 200 | 40 | 68 | 34 | 8 | 78 | 89 | 46 | 33,19 | 12 | 35 | 47 | 15 |
| Brazil | 1995–2004 | 164 | 34 | 80 | 104 | 18 | ND | 95 | 3 | 34,29 | 10 | 75 | 61 | 17 |
| France† | 1985–1994 | 40 | 38 | 78 | 32 | 0 | 17 | 88 | 49 | 48, 36 | 56 | 60 | 40 | 15 |
| France† | 1997–2006 | 64 | 40 | 58 | 28 | 23 | 42 | 84 | 63 | 43, 44 | 44 | 34 | 36 | 11 |
| Area | Period | No. | AIDS-defining, % | Mortality, % (follow-up, months) | Relapse | Mean for diagnosis, % | ||
|---|---|---|---|---|---|---|---|---|
| Blood culture | Histology | Urinary/blood antigen detection | ||||||
| Indiana, USA | 1981–1989 | 72 | 69 | 22 (NA) | 18 (NA) | 90 (19) | NA | 97, 83 |
| United States | 1996–1999 | 92 | > 50 | 12 (3) | NA | 71 (51) | NA | 96, 85 |
| Colombia | 1979–2001 | 30 | ND | 20 (12) | NA | 96 | 81 | NA |
| Panama | 1997–2003 | 104 | 68 | 10 (1) | 6 (NA) | NA (68) | 34 | NA |
| French Guiana | 1982–2007 | 200 | 78 | 31 (6) | NA | NA (8) | NA | NA |
| Brazil | 1995–2004 | 164 | ND | 32 (NA) | NA | 48 (NA) | 81 | NA |
| France† | 1985–1994 | 40 | 17 | 53 (12) | 5 | 78 (35) | 95 | NA |
| France† | 1997–2006 | 64 | 42 | 22 (12) | 6 | 81 (54) | 94 | NA |
*
HAART = highly active anti-retroviral therapy; AIDS = acquired immunodeficiency syndrome; Adp = adenopathy; HM = hepatomegaly; SM = splenomegaly; Pulm = pulmonary symptoms; Abdo = abdominal symptoms; Neuro = neurologic symptoms; NA = not available.
†
This study.