Table 3.
Genotype distribution of NPY polymorphism of dampness-phlegm and non-dampness-phlegm.
| Model | SNPs | Genotype | Normal | Non-dampness-phlegm | cOR [95% CI] | sig.a | Dampness-phlegm | dOR [95% CI] | sig.b |
|---|---|---|---|---|---|---|---|---|---|
| Allele | G-1484A | G | 682 (68.75) | 544 (68) | 0.988 | 0.9145 | 294 (74.24) | 0.748 | 0.0524 |
| A | 310 (31.25) | 256 (32) | [0.787, 1.240] | 102 (25.76) | [0.558, 1.003] | ||||
| C-1471T | C | 824 (82.90) | 663 (83.29) | 1.051 | 0.7314 | 323 (81.98) | 0.931 | 0.6867 | |
| T | 170 (17.10) | 133 (16.71) | [0.791, 1.398] | 71 (18.02) | [0.656, 1.320] | ||||
| C-399T | C | 666 (67.0) | 535 (66.88) | 1.007 | 0.9511 | 288 (72.73) | 0.737 | 0.0378 | |
| T | 328 (33.0) | 265 (33.13) | [0.804, 1.261] | 108 (27.27) | [0.552, 0.983] | ||||
| A1201G | A | 653 (65.83) | 497 (62.13) | 0.868 | 0.2099 | 272 (68.69) | 0.879 | 0.3666 | |
| G | 339 (34.17) | 303 (37.88) | [0.696, 1.083] | 124 (31.31) | [0.664, 1.163] | ||||
| C5325T | C | 682 (68.75) | 534 (66.75) | 0.851 | 0.1658 | 250 (63.13) | 1.250 | 0.1131 | |
| T | 310 (31.25) | 266 (33.25) | [0.678, 1.069] | 146 (36.87) | [0.948, 1.648] | ||||
|
| |||||||||
| †Do | G-1484A | GG | 240 (48.39) | 181 (45.25) | 0.93 | 0.6363 | 110 (55.56) | 0.697 | 0.0583 |
| GA+AA | 256 (51.61) | 219 (54.75) | [0.688, 1.257] | 88 (44.44) | [0.480, 1.013] | ||||
| C-1471T | CC | 338 (68.01) | 276 (69.35) | 1.058 | 0.7319 | 135 (68.53) | 0.918 | 0.6762 | |
| CT+TT | 159 (31.99) | 122 (30.65) | [0.765, 1.465] | 62 (31.47) | [0.614, 1.373] | ||||
| C-399T | CC | 232 (46.68) | 176 (44) | 0.953 | 0.7569 | 107 (54.04) | 0.663 | 0.0315 | |
| CT+TT | 265 (53.32) | 224 (56) | [0.705, 1.29] | 91 (45.96) | [0.456, 0.964] | ||||
| A1201G | AA | 225 (45.36) | 158 (39.5) | 0.821 | 0.2059 | 95 (47.98) | 0.862 | 0.4357 | |
| AG+GG | 271 (54.64) | 242(60.5) | [0.605, 1.114] | 103 (52.02) | [0.594, 1.252] | ||||
| C5325T | CC | 241 (48.59) | 179 (44.75) | 0.794 | 0.1335 | 76 (38.38) | 1.557 | 0.0210 | |
| CT+TT | 255 (51.41) | 221 (55.25) | [0.587, 1.073] | 122 (61.62) | [1.069, 2.269] | ||||
|
| |||||||||
| †R | G-1484A | GG+GA | 442 (89.11) | 363 (90.75) | 1.148 | 0.5868 | 184 (92.93) | 0.700 | 0.2961 |
| AA | 54(10.89) | 37 (9.25) | [0.697, 1.89] | 14 (7.07) | [0.359, 1.366] | ||||
| C-1471T | CC+CT | 486 (97.79) | 387 (97.24) | 1.077 | 0.8826 | 188 (95.43) | 0.937 | 0.9019 | |
| TT | 11 (2.21) | 11 (2.76) | [0.404, 2.868] | 9 (4.57) | [0.330, 2.656] | ||||
| C-399T | CC+CT | 434 (87.32) | 359 (89.75) | 1.157 | 0.5444 | 181 (91.41) | 0.750 | 0.3579 | |
| TT | 63 (12.68) | 41 (10.25) | [0.722, 1.853] | 17 (8.59) | [0.406, 1.385] | ||||
| A1201G | AA+AG | 428 (86.29) | 339 (84.75) | 0.869 | 0.518 | 177 (89.39) | 0.830 | 0.5201 | |
| GG | 68 (13.71) | 61 (15.25) | [0.568, 1.33] | 21 (10.61) | [0.469, 1.466] | ||||
| C5325T | CC+CT | 441 (88.91) | 355 (88.75) | 0.878 | 0.5966 | 174 (87.88) | 0.907 | 0.7457 | |
| TT | 55 (11.09) | 45 (11.25) | [0.544, 1.419] | 24(12.12) | [0.503, 1.636] | ||||
Data are presented as frequencies (percentages). cORs after adjustment for sex, age, drinking, and smoking with normal versus non-dampness-phlegm. dORs after adjustment for sex, age, drinking, and smoking with normal versus dampness-phlegm. sig.a: P value of normal versus non-dampness-phlegm using multiple logistic regression analysis. sig.b: P value of normal versus dampness-phlegm using multiple logistic regression analysis. †Do and R denote dominant and recessive models, respectively. CI: confidence interval. P-values with statistical significance were presented in bold (<0.05).