Table 3.

Optimization of the reaction of vinyl azide 4b in the inductively heated (IH) copper-catalyzed Huisgen-type cycloaddition.

entry	catalyst	solvent	flow rate [mL/min]	T [°C]	yield [%]
1	Cu-wire	DMF	0.04	70	32
2	Cu-turnings	DMF	0.04	80	72
3	Cu-turnings	DMF	0.07	80	44
4	Cu-turnings	DMF	0.04	100	23
5	Cu-turnings	DMF	0.04	110	10
6	Cu-turnings	acetone	0.04	80	59
7	Cu-turnings	dioxane	0.04	80	55
8	Cu-turnings/0.2 equiv CuSO4	DMF/H2O 1:1	0.04	80	58
9	Cu-turnings/1 equiv DIPEA	DMF	0.04	80	68