Table 8.

Adverse Events at Baseline and During Treatment with the Three Methylphenidate Preparations in the Safety Analysis Population

	Baseline	Medikinet retard in equivalent daily dose	Medikinet retard in reduced daily dose	Concerta
Number of children and adolescents treated	113	108	106	110
Number of adverse events	32	41	61	65
Number of children and adolescents with adverse events	24	33	40	39
Most common adverse events (n≥5)
Headache	3	8	3	10
Gastrointestinal pain	3	6	7	5
Decreased appetite	4	3	3	7
Initial insomnia	1	3	3	6
Aggression	1	2	3	5
Fatigue	2	0	4	3
Disturbance in attention	0	0	3	5
Restlessness	0	1	5	2
Anorexia	3	0	0	4
Nasopharyngitis	1	2	2	1
Weight loss	0	0	3	2