Table 3.
Symptom Measures at Baseline and Week 6 for 12 Subjects Treated with Olanzapine
| Baseline (mean SD) | End of trial (mean SD) | Within subjects p value | Effect size (baseline to end) of trial) | |
|---|---|---|---|---|
| YGTSS–Motor Tic Category | ||||
| Number | 4.33 ± 0.49 | 3.08 ± 1.73 | 0.015** | 0.44 |
| Frequency | 4.75 ± 0.62 | 3.58 ± 1.83 | 0.003** | 0.39 |
| Intensity | 3.75 ± 0.75 | 2.58 ± 1.51 | 0.029** | 0.44 |
| Complexity | 3.33 ± 0.78 | 2.42 ± 1.24 | 0.037** | 0.40 |
| Interference | 3.17 ± 1.11 | 2.08 ± 1.44 | 0.021** | 0.39 |
| Total Motor Tic Severity Score | 19.33 ± 2.61 | 13.75 ± 7.06 | 0.006** | 1.04 |
| YGTSS–Vocal Tic Category | ||||
| Number | 2.17 ± 1.19 | 1.58 ± 1.00 | 0.222 | 0.26 |
| Frequency | 3.5 ± 1.34 | 2.75 ± 1.42 | 0.223 | 0.26 |
| Intensity | 2.83 ± 1.33 | 2.08 ± 1.24 | 0.389 | 0.40 |
| Complexity | 1.83 ± 1.59 | 1.25 ± 1.48 | 0.368 | 0.19 |
| Interference | 2.25 ± 1.48 | 1.08 ± 1.16 | 0.030** | 0.40 |
| Total Tic Severity Score | 12.58 ± 6.35 | 8.75 ± 5.10 | 0.085* | 0.67 |
| YGTSS–Total Tic Category | ||||
| Number | 6.5 ± 1.51 | 4.67 ± 2.19 | 0.121 | 0.44 |
| Frequency | 8.25 ± 1.54 | 6.33 ± 2.77 | 0.014** | 0.39 |
| Intensity | 6.58 ± 1.68 | 4.67 ± 1.92 | 0.047** | 0.47 |
| Complexity | 5.17 ± 1.90 | 3.67 ± 1.67 | 0.135 | 0.39 |
| Interference | 5.42 ± 1.83 | 3.17 ± 2.17 | 0.006** | 0.49 |
| Total Tic Severity Score | 31.92 ± 7.39 | 22.50 ± 9.37 | 0.010** | 0.49 |
| YGTSS–Overall Functioning Category | ||||
| Overall Impairment Rating | 33.33 ± 10.73 | 20.50 ± 13.73 | <0.001*** | 0.46 |
| Global Severity | 65.25 ± 14.12 | 43.00 ± 21.47 | <0.001*** | 0.52 |
| SNAP IV Rating Scale Category–Parent | ||||
| ADHD Inattention | 1.92 ± .67 | 1.29 ± 0.62 | <.001*** | 0.44 |
| ADHD Hyperactivity/Impulsivity | 1.39 ± .87 | 0.69 ± 0.59 | <0.001*** | 0.43 |
| ODD | 1.27 ± .88 | 0.61 ± 0.39 | 0.001*** | 0.43 |
| Inattention/Overactivity | 1.93 ± .73 | 1.22 ± 0.71 | 0.002*** | 0.45 |
| Aggression/Defiance | 1.25 ± .65 | 0.67 ± 0.42 | 0.009*** | 0.47 |
| Conners' Index | 1.46 ± .56 | 0.90 ± 0.51 | <0.001*** | 0.46 |
| OAS score | ||||
| Total | 15.82 ± 24.31 | 7.58 ± 11.71 | 0.199 | 0.43 |
| Number of episodes | 2.91 ± 3.42 | 1.33 ± 1.5 | 0.011** | 0.59 |
| MASC score–Child | ||||
| Physical Symptoms | 52.75 ± 11.07 | 48.58 ± 11.23 | 0.047** | 0.37 |
| Harm Avoidance | 51.92 ± 10.05 | 47.83 ± 10.6 | 0.681 | 0.50 |
| Social Anxiety | 58.50 ± 11.18 | 57.83 ± 14.31 | 0.822 | 0.05 |
| Separation Anxiety/Panic | 56.75 ± 11.55 | 57.50 ± 10.15 | 0.110 | 0.07 |
| Total Score | 56.67 ± 11.71 | 53.50 ± 11.34 | 0.331 | 0.28 |
| MASC score–Parent | ||||
| Physical Symptoms | 47.73 ± 7.30 | 48.42 ± 8.44 | 0.251 | 0.09 |
| Harm Avoidance | 48.27 ± 10.01 | 46.83 ± 12.94 | 0.551 | 0.12 |
| Social Anxiety | 60.64 ± 10.98 | 59.92 ± 9.36 | 0.134 | 0.07 |
| Separation Anxiety/Panic | 56.27 ± 9.87 | 53.08 ± 10.17 | 0.236 | 0.32 |
| Total Score | 53.91 ± 10.06 | 53.67 ± 9.55 | 0.316 | 0.02 |
Means, standard deviations, p values, and effect size. Weekly comparison of motor tic, vocal tic, total tic, impairment, global severity, parent SNAP-IV subcategory scores, and OAS Scores using repeated measures analyses. Indicated p values are post-Bonferroni correction. N = 12. SNAP scores are presented as average score per individual item.
SD = standard deviation; YGTSS = Yale Global Tic Severity Scale; SNAP IV = Swanson, Nolan and Pelham Questionnaire revision; OAS = Overt Aggression Scale; MASC = Multidimensional Anxiety Scale for Children.
**
less than .05; ***less than .001.