Figure 1.

P301S transgenic mice showed hyperactivity and disinhibition. A–F) Total distance traveled (A–C) and rearing frequency (D–F) in the open-field test at 2 mo (A, D), 7 mo (B, E), and 10 mo (C, F). P301S (Tg) mice were hyperactive compared to wild-type (Wt) littermates at 7 and 10 mo. G–L) Frequency of entries in closed and open arms (G–I), as well as percentage of time spent in open arms (J–L), in the elevated plus maze at at 2 mo (G, J), 7 mo (H, K), and 10 mo (I, L). P301S mice were hyperactive and disinhibited compared to wild-type littermates at 7 and 10 mo. Data are expressed as means ± se.