Figure 2.

P301S transgenic mice did not present major cognitive deficits. Acquisition period (A–C) and probe trial (D–F) of the Morris water maze in which latency to reach the hidden platform and percentage of time spent in each quadrant were recorded at 2 mo (A, D), 7 mo (B, E), and 10 mo (C, F). No difference was found between P301S (Tg) mice and wild-type (Wt) littermates in the Morris water maze. However, trend indicated increased latency to reach the platform in P301S mice at 10 mo. Data are expressed as means ± se.