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Tau accumulation and tangles were increased with age in P301S transgenic mice. MC1 immunoreactivity in the somatosensory and piriform cortices, the CA1 region of the hippocampus, and the central amygdala of 7-mo-old wild-type (Wt) mice, as well as 2-, 7-, and 10-mo-old P301S (Tg) mice. Scale bars = 250 μm. Higher-magnification photographs were taken in 10-mo-old P301S mice to visualize tangles. MC1 immunoreactivity increased from 2 to 10 mo in P301S mice.
