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. 2011 Nov;25(11):4048–4062. doi: 10.1096/fj.11-191627

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Figure 8. — Salivary gland epithelial cell Cl⁻ secretion. A) Expression of TMEM16A in human salivary gland. Left panel: TMEM16A immunostaining in human parotid gland. Scale bar = 20 μm. Right panel: immunoblot of TMEM16A in FRT-TMEM16A and A253 cells. B) Whole-cell patch-clamp recordings in A253 cells. Left panel: CaCC and TMEM16A chloride current induced by 100 μM ATP and 10 μM E_act, respectively. Right panel: current/voltage (I/V) plot of mean currents at the middle of each voltage pulse (voltages between −80 and +80 mV in steps of 20 mV).