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γ-Tubulin protein levels regulate E2F transcriptional activity. A) In the absence of γ-tubulin, at G1/S phase transition, the released E2F-Dp1 complex transcribes RB. B) In the presence of γ-tubulin, at G1/S transition, the released E2F-Dp1 complex transcribes gene products necessary for S-phase entry, such as cyclin E. As nuclear γ-tubulin levels increase, the E2F–γ-tubulin complex forms and puts an end to the transcriptional activity of E2Fs.
