Fig. 5.
Correlations and connectivity between communication factors in CSF and plasma are different in AD patients compared with NDC. A, Spearman rank correlations (correlation coefficient RS) between CSF and plasma in nondemented controls (green bars) and AD patients (blue bars). Proteins with RS ≥ 0.5 in at least one group are shown. RS ≤ –0.5 were not observed. Note that levels of CCL5 and ICAM-1 correlate much stronger in AD than in NDC across the BBB and that ApoH and CCL2 reach RS = 0.5 in AD but not in NDC. B, C, Connectivity diagrams illustrating correlations between CSF communication factors selected in models C1–C5 and plasma communication factors selected in models P6–P10. In parentheses are the interaction scores. See legend to Fig. 2 for more details on calculations. Note the considerable lack and difference in connectivity between communication factors in AD patients (C) compared with NDC (B). See also supplemental Fig. S1. BBB, blood-brain barrier.