Fig. 5.

A, Using 56 proteins that were targeted by both the virus HIV-1 and the parasite P. falciparum we constructed a bipartite matrix. Specifically, we indicated a link if a pair of a virus and parasite proteins shared at least one common host protein. Specifically, we observed that Vif, Tat, matrix, gp160 and Nef shared the majority of targeted proteins with the parasite. B, On a qualitative basis, we mapped interactions between pathogen and host proteins if a host protein shared interactions with both the virus and the parasite. We observed a large assembly of interactions with proteasomal proteins and viral proteins Tat and Vif. Although the parasite interacted with proteasomal subunits as well interactions were distributed among many different parasite proteins. In addition, we found numerous signaling and regulation proteins that interacted with a variety of parasite and viral proteins.