Fig. 3.

Protein interaction networks of ubiquitylated proteins. Network interaction analysis was performed using protein interaction information from the STRING database. Ubiquitylated proteins were grouped using associated GO biological process terms, and interaction subnetworks were visualized using Cytoscape. The networks show identified ubiquitylated proteins implicated in DNA replication (A) and DNA repair (B). The node size represents the number of identified ubiquitylation sites on each protein. Selected, functionally important protein core complexes are color coded in red.