Fig. 6.

Site-specific crosstalk between ubiquitylation and acetylation. A, Overlap between ubiquitylation sites identified in this study and a previously published dataset of acetylation sites. B, Effect of acetylation-ubiquitylation overlap on proteasomal degradation. The SILAC ratio distribution of ubiquitylation sites after treatment with proteosome inhibitor MG-132 is compared for sites that were identified as ubiquitylated, or sites that were identified as both ubiquitylated and acetylated. C, Functional annotations of proteins modified by ubiquitylation and acetylation at the same lysine. Significantly enriched GO cellular compartment (CC), GO biological process (BP) and GO molecular function (MF) terms are shown.