Table 2.
Genes displaying significant expression differences in both the MEN1-associated and sporadic pituitary adenomas
| MEN1 tumor | Sporadic tumor | Map | Gene | Gene identity |
|---|---|---|---|---|
| Fold increase | ||||
| 2.40 | 0.30 | Xq26.1-q27.2 | HTATSF1 | HIV-1 Tat specific factor 1 |
| 2.54 | 0.29 | 20p11.22-p11.21 | C20orf3 | Chromosome 20 open reading frame 3 |
| 3.02 | 0.26 | 14q24.3 | FOS | FBJ murine osteosarcoma viral oncogene homolog |
| 3.44 | 0.86 | 10pter-q22.1 | KIF5B | Kinesin family member 5B |
| 7.73 | 0.43 | 13q13 | DCLK1 | Doublecortin-like kinase 1 |
| Fold decrease | ||||
| 0.03 | 0.01 | 6q12-q21 | CGA | Glycoprotein hormones, α polypeptide |
| 0.06 | 0.04 | 11p13 | FSHB | FSH, β polypeptide |
| 0.17 | 0.13 | Xq26.1 | GPC4 | Glypican 4 |
| 0.18 | 0.25 | 5q31 | PITX1 | Paired-like homeodomain 1 |
| 0.19 | 0.01 | 19q13.32 | CGB5 | Chorionic gonadotropin, β polypeptide 5 |
| 0.19 | 0.25 | 21q22.3 | COL6A1 | Collagen, type VI, α 1 |
| 0.20 | 0.33 | Xq26.1 | GPC3 | Glypican 3 |
| 0.21 | 0.44 | 20q11.2-q12 | NNAT | Neuronatin |
| 0.22 | 0.14 | 4q22.1 | SPARCL1 | SPARC-like 1 (mast9, hevin) |
| 0.25 | 0.03 | 12p13.1-p12.3 | MGP | Matrix Gla protein |
| 0.27 | 0.09 | 1p36.1-p35 | HSPG2 | Heparan sulfate proteoglycan 2 |
| 0.28 | 0.18 | 5q32 | CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain |
| 0.30 | 0.07 | 6p21.3 | HLA-DRB5 | Major histocompatibility complex, class II, DR β 5 |
| 0.39 | 0.17 | 6p21.3 | HLA-DRB3 | Major histocompatibility complex, class II, DR β 3 |
| 0.42 | 0.20 | 3q26.2-qter | APOD | Apolipoprotein D |
| 0.43 | 0.13 | 6p21.3 | HLA-DRA | Major histocompatibility complex, class II, DR α |