Table 3.
Genes displaying significant expression differences in the MEN1-associated pituitary adenoma only
| Map | Gene | Gene identity | |
|---|---|---|---|
| Fold increase | |||
| 2.02 | 17q | CBX1 | Chromobox homolog 1 (HP1 β homolog Drosophila) |
| 2.20 | 3p21.31 | SPCS1 | Signal peptidase complex subunit 1 homolog (Saccharomyces cerevisiae) |
| 2.34 | 17q23.1-q23.3 | KPNA2 | Karyopherin α 2 (RAG cohort 1, importin α 1) |
| 2.50 | 22q12.3 | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, η polypeptide |
| 2.55 | 2q33-q34 | EEF1B2 | Eukaryotic translation elongation factor 1 β 2 |
| 2.71 | 8p21.2 | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4 |
| 2.73 | 7p15-p12 | ACTB | Actin, β |
| 2.79 | 15q13-q14 | SCG5 | Secretogranin V (7B2 protein) |
| 2.85 | 6p21.1 | SRF | Serum response factor (c-fos serum response element-binding transcription factor) |
| 2.86 | 17q21.3 | NME1 | Nonmetastatic cells 1, protein (NM23A) expressed in |
| 2.91 | 8p21-p12 | EPHX2 | Epoxide hydrolase 2, cytoplasmic |
| 2.93 | 9q22-q31 | ZNF189 | Zinc finger protein 189 |
| 2.98 | 13q14.3 | ITM2B | Integral membrane protein 2B |
| 3.00 | 8q21 | TPD52 | Tumor protein D52 |
| 3.11 | 1q21 | MLLT11 | Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
| 3.12 | 9q34.11 | RABEPK | Rab9 effector protein with kelch motifs |
| 3.34 | 9q21.13 | RFK | Riboflavin kinase |
| 3.34 | 1p36.1 | DDOST | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase |
| 3.40 | Xp11.2 | RBM3 | RNA binding motif (RNP1, RRM) protein 3 |
| 3.42 | 7q21-q22 | SGCE | Sarcoglycan, ϵ |
| 3.43 | 11p13 | RCN1 | Reticulocalbin 1, EF-hand calcium binding domain |
| 3.47 | 12q22-q23 | DUSP6 | Dual specificity phosphatase 6 |
| 3.51 | 20q13.2-q13.3 | GNAS | GNAS complex locus |
| 3.66 | 10q11.21 | BMS1 | BMS1 homolog, ribosome assembly protein (yeast) |
| 3.68 | 9q34.11 | ARPC5 L | Actin-related protein 2/3 complex, subunit 5-like |
| 3.70 | 19p13.2 | ZNF177 | Zinc finger protein 177 |
| 3.74 | 10p13 | CELF2 | CUGBP, Elav-like family member 2 |
| 3.76 | 19q13.1 | SPINT2 | Serine peptidase inhibitor, Kunitz type, 2 |
| 3.90 | 18p11.2 | IMPA2 | Inositol(myo)-1(or 4)-monophosphatase 2 |
| 3.91 | 14q24.1-q24.3 | ARG2 | Arginase, type II |
| 3.92 | 14q11.2 | IRF9 | Interferon regulatory factor 9 |
| 3.95 | 1q21 | SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 |
| 4.21 | 19p13.3 | MIDN | Midnolin |
| 4.30 | 12q12-q13 | CD63 | CD63 molecule |
| 4.33 | 1p31.3 | LEPROT | Leptin receptor overlapping transcript |
| 4.47 | 12q12 | SLC38A1 | Solute carrier family 38, member 1 |
| 4.51 | 11p11 | GNG3 | Guanine nucleotide binding protein (G protein), γ 3 |
| 4.59 | 5q13 | THBS4 | Thrombospondin 4 |
| 5.05 | 1q21.3 | PBXIP1 | Pre-B-cell leukemia homeobox interacting protein 1 |
| 5.06 | 15q21-q22.2 | B2M | β-2-microglobulin |
| 5.53 | 1p31.2-p31.1 | GADD45A | Growth arrest and DNA-damage-inducible, α |
| 5.91 | Xq13.1-q28 | IL13RA2 | Interleukin 13 receptor, α 2 |
| 6.02 | 9q13 | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase, type I, β |
| 6.05 | 3q13.33 | SLC15A2 | Solute carrier family 15 (H+/peptide transporter), member 2 |
| 6.74 | 6q23 | SGK1 | Serum/glucocorticoid regulated kinase 1 |
| 6.80 | 19q13.32 | FOSB | FBJ murine osteosarcoma viral oncogene homolog B |
| 7.09 | 12q24.13 | ERP29 | Endoplasmic reticulum protein 29 |
| 7.15 | 15q24-q25 | CTSH | Cathepsin H |
| 8.72 | 12q21 | NTS | Neurotensin |
| 9.10 | 6p21.3 | HLA-B | Major histocompatibility complex, class I, B |
| 9.58 | 6q27 | THBS2 | Thrombospondin 2 |
| 10.57 | 10q25 | DUSP5 | Dual specificity phosphatase 5 |
| 11.08 | 7q22 | VGF | VGF nerve growth factor inducible |
| 11.78 | 8q23-q24 | PENK | Proenkephalin |
| Fold decrease | |||
| 0.09 | 9p22 | SH3GL2 | SH3-domain GRB2-like 2 |
| 0.20 | 16q22.1 | CDH1 | Cadherin 1, type 1, E-cadherin (epithelial) |
| 0.22 | 16q22.1 | HP | Haptoglobin |
| 0.32 | 17q12-q21.1 | IGFBP4 | IGF binding protein 4 |
| 0.36 | 11p11.2 | MDK | Midkine (neurite growth-promoting factor 2) |
| 0.45 | Xq22-q24 | PGRMC1 | Progesterone receptor membrane component 1 |
| 0.60 | 1p13.3 | GSTM2 | Glutathione S-transferase μ 2 (muscle) |