Table 1.
Amyloid protein1 | Precursor | Systemic (S) or localized (L) | Organ involvement | Aetiology | Treatment options |
---|---|---|---|---|---|
AL | Immunoglobulin kappa or lambda light chain | S, L | Cardiac, renal, hepatic, PNS, and soft tissues | Primary or myeloma associated | Chemotherapy, stem cell transplant |
ATTR | Transthyretin | S | Cardiac, PNS, GIT, CTS | Hereditary | Liver transplant |
ATTR | Transthyretin | S | Cardiac, CTS | Senile | Supportive care |
AA | (Apo)serum amyloid A | S | Renal | Secondary to chronic inflammation | Control inflammation |
1Recommended amyloid protein nomenclature includes prefix A [3]. PNS: peripheral nervous system; GIT: gastrointestinal tract; CTS: carpal tunnel syndrome.