Table 4.
Metastatic enriched (relative to primary) Gene-Ontology (GO) terms with FDR less than 5% and p value less than 0.05 are shown in bold. The differentially abundant proteins associated with each cluster are presented with their Swiss-Prot accession number.
| Cluster Description and Associated Proteins | Enrichment Score | p-value | FDR (%) | ||
|---|---|---|---|---|---|
| Cluster 1: Cytoplasmic vesicle | 4.45 | 1.24E-05 | 0.02 | ||
| P30040 | Endoplasmic reticulum protein ERp29 | Q8NEW0 | Zinc transporter 7 | ||
| P61106 | Ras-related protein Rab-14 | P49755 | Transmembrane emp24 domain-containing protein 10 | ||
| P07339 | Cathepsin D | P09622 | Dihydrolipoyl dehydrogenase, mitochondrial | ||
| P10909 | Clusterin | Q9NZM1 | Myoferlin | ||
| P53621 | Coatomer subunit alpha | Q15084 | Protein disulfide-isomerase A6 | ||
| P53618 | Coatomer subunit beta | O95716 | Ras-related protein Rab-3D | ||
| O14579 | Coatomer subunit epsilon | P02751 | Fibronectin | ||
| Q9Y678 | Coatomer subunit gamma | P08133 | Annexin A6 | ||
| P11142 | Heat shock cognate 71 kDa protein | ||||
| Cluster 2: Vesicle targeting, to, from or within Golgi, Golgi vesicle transport, vesicle localization | 2.19 | 2.25E-04 | 0.03, 0.15, 0.24a | ||
| P55735 | Protein SEC13 homolog | P05783 | Keratin, type I cytoskeletal 18 | ||
| Q92538 | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 | P54920 | Alpha-soluble NSF attachment protein | ||
| Cluster 3: Signal peptide | 1.84 | 2.52E-03 | 3.53 | ||
| Q9Y3A6 | Transmembrane emp24 domain-containing protein 5 | Q9BRX8 | Uncharacterized protein C10 or f58 | ||
| Q9Y3B3 | Transmembrane emp24 domain-containing protein 7 | Q15392 | 24-dehydrocholesterol reductase | ||
| P12111 | Collagen alpha-3(VI) chain | Q8TD06 | Anterior gradient protein 3 homolog | ||
| P12110 | Collagen alpha-2(VI) chain | Q12907 | Vesicular integral-membrane protein VIP36 | ||
| P12109 | Collagen alpha-1(VI) chain | P24821 | Tenascin | ||
| Cluster 4: ECM-receptor interaction, extracellular matrix | 1.59 | 3.78E-03 | 1.69, 4.73a | ||
| P12111 | Collagen alpha-3(VI) chain | P12109 | Collagen alpha-1(VI) chain | ||
| P12110 | Collagen alpha-2(VI) chain | P24821 | Tenascin | ||
| Cluster 5: Glycolysis pathway | 1.40 | 6.20E-03 | 3.34 | ||
| P60174 | Triose phosphate isomerase | P06733 | Alpha-enolase | ||
| P00558 | Phosphoglycerate kinase 1 | ||||
a
Multiple FDRs resulting from multiple units within the cluster.