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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Struct Biol. 2011 Jun 17;175(3):353–361. doi: 10.1016/j.jsb.2011.06.004

Figure 6.

Figure 6

Example illustrating algorithm bias. a) Three good particles on the micrograph; b) Two particles found by LFCPick and manually verified as correct, giving 100% sensitivity; c) Two particles found by DoGLFC, which were verified as correct since they overlap with the windows verified in (b); in other words, not by a separate manual verification. Here DoGLFC has made two errors, (i) locating an unverified particle and (ii) missing a verified one. This toy example illustrates why the score of the DoGLFC performance is pessimistic.