. Author manuscript; available in PMC: 2011 Nov 1.

Published in final edited form as: J Chromatogr A. 2007 Aug 30;1168(1-2):3–2. doi: 10.1016/j.chroma.2007.08.054

Table 6.

Summary of Thermally Stable RPLC Phases

Name of phase	Particle size (μm)	Thermo-Chemical^a Stability	Efficiency	Selectivity^b vs. C₁₈	Thermal-Mechanical^c Stability
Agilent SB	1.8, 3.5, 5 and 7	+	++	Similar	+
Agilent Extend	1.8, 3.5, 5 and 7	+	++	Similar	+
Waters X-bridge	2.5, 3.5, 5 and 10	+	++	Similar	+
Zirchrom PBD, PS	2.5, 3.5, 5 and 10	++	++	Different	+
Zirchrom Carb	3, 5, 10 and 25	++	0	Different	+
Zirchrom Diamondbond	3, 5, 10 and 25	++	+	Different	+
Thermo Electron Hypercarb	3, 5 and 7	+	0	Different	-
Hamilton Polymer reversed phases	3, 10 and 12-20	+	-	Different	-
Selerity Blaze	3 and 5	+	?	Similar	+

This refers to the chemical integrity of the column under the stress of elevated temperature specifically the loss of the retentive phase or modification of the column. Basically, how constant is retention.

This refers to how similar retention order is relative to a typical octodecyl-like silane bonded phase.

It is found that repeated heating and cooling of hot column and imposition of eluent gradients can cause a grievous decrease in column efficiency, even though there is no decrease in retention. This has been found to be especially problematic with narrow bore (2.1 mm) column.