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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Nat Commun. 2010 Jul 27;1:41. doi: 10.1038/ncomms1042

Figure 4. Multimodality imaging using the MNP-gold hybrid NPs.

Figure 4

(a&b) Dark-field imaging of single MNPs spread on glass coverslips before and after gold nanoshell coating. The coated MNPs are readily detectable under current experiment conditions (insets show corresponding TEM images). (c) T2-weighted MR images of the bare and gold-coated MNPs at various dilutions. The signal strength is indicated by the darkness of the images. At the same concentrations, the MR images are indistinguishable between the two series indicating unchanged magnetic properties before and after gold nanoshell coating. (d&e) Cross-sectional PA images of a tube filled with (d) 5 nM MNPs and (e) 5 nM MNP-gold NPs on a dB scale. 0 dB corresponds to the maximum signal level among both images. Note that a different dynamic range was used for better visualization. Signal-to-noise ratio can be improved by 1 order of magnitude (20 dB) when MNP-gold NPs are used.