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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Am J Transplant. 2011 Sep 11;11(10):2012–2019. doi: 10.1111/j.1600-6143.2011.03727.x

Figure 1. Proposed model of TIM-1 signaling in activated T cells.

Figure 1

Upon ligation, tyrosine kinase residues in the TIM-1 cytoplasmic domain become phosphorylated. This leads to activation of Akt and ERK/MAPK which results in enhanced IL-2 and IL-4 transcription. In addition, TIM-1 ligation itself may be sufficient to initiate T cell activation through CD3 capping and increased phosphorylation of adaptor proteins associated with the TCR complex. Overall, TIM-1 signaling leads to enhanced T cell activation and proliferation, but the nature of the resulting T helper cell differentiation appears to be dependent on the susceptibility of the model system studied.

Inset: Domain structure of a TIM family member.

TIM members are composed of an IgV domain, mucin domain, transmembrane domain and cytoplasmic domain. Additionally, TIM-1 and TIM-3 possess tyrosine kinase phosphorylation motifs within their cytoplasmic domains.