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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: J Med Chem. 2009 Oct 22;52(20):6244–6256. doi: 10.1021/jm901031h

Figure 5.

Figure 5

A: determination of apoptotic and non-apoptotic cell death levels in U373 GBM cells after 72 hrs in presence of 5 (Lyc − 5 μM) and 50 (Lyc − 50 μM) μM lycorine as compared to control (absence of lycorine). Human MCF-7 breast cancer cells treated with 1 μM narciclasine for 72 hrs used as positive control (+ Control). U373 cells were stained with propidium iodide (PI) and Annexin-V (AV). Early apoptosis corresponds to AV+/PI- U373 cells, while late apoptosis corresponds to AV+/PI+ U373 cells. Non-apoptotic cell death corresponds to AV-/PI+ cells. Data are presented as means ± SEMs. Ba and Bb: the behavior of two individual U373 GBM cells cultured in presence of 50 μM lycorine was monitored for 72 hrs.