A: body weight measurements of mice having received i.v. administrations (tail vein; three mice per group) of 5, 10, 20, 40 and 80 mg/kg lycorine during 5 consecutive days. Data are presented as means ± SEMs. No single mouse died over a 28-day period of observation and the mice did not loose weights, emphasizing absence of lycorine-induced toxicity. B: Survival analyses of mice orthotopically grafted into their brains with the mouse melanoma B16F10 which have been left untreated (control; the black dots) or treated 3 times a week (Monday, Wednesday, Friday) during 3 consecutive weeks (treatment starting the 5th day post-tumor graft) with 5 mg/kg (the maximal tolerated dose) cisplatin (intraperitoneal administrations) or 40 mg/kg lycorine (i.v. administrations into the tail vein). There were 11 mice per experimental group.