Table 4.

Ratio of pulse wave velocity compared with reference tertile (95% confidence interval) by tertiles of serum osteoprotegerin (n = 226)

Modela	Tertile 1 (1.21 to 5.03 pmol/L)	Tertile 2 (5.05 to 7.45 pmol/L)	Tertile 3 (7.46 to 22.31 pmol/L)	P Trend
Unadjusted	Refc	1.19d (1.10, 1.30)	1.30d (1.20, 1.42)	<0.001
Traditional vascular risk factor adjusted	Refc	1.09d (1.01, 1.17)	1.15d (1.06, 1.25)	0.001
Traditional/nontraditional risk factor adjusted	Refc	1.06 (0.98, 1.14)	1.11d (1.02, 1.20)	0.01
Cortical bone mineral content adjustedb	Refc	1.06 (0.97, 1.15)	1.10d (1.01, 1.20)	0.04

^aTraditional vascular risk factor adjusted model adjusted for age, gender, race, diabetes, history of cardiovascular disease, history of hypertension, current/former smoking, and systolic blood pressure; traditional/nontraditional risk factor adjusted model adjusted for traditional risk factors above plus estimated GFR, albuminuria, serum albumin, log(C-reactive protein), serum phosphate, corrected serum calcium, and presence of secondary hyperparathyroidism.

^bCortical bone mineral content adjusted model adjusted for traditional/nontraditional risk factors above plus and cortical bone mineral content in the subset with quantitative computed tomography available (n = 161).

^cNote reference = 1.0.

^dP < 0.05.