Table 3. Resistance profile and mutations in M. smegmatis mutants showing lower levels of resistance to DNB.
M. smegmatis strain | Mutation in MSMEG_6503 | DNB3 MIC (µg/ml) | BTZ-043 MIC (µg/ml) |
mc2155 | - | 0.25 | 0.004 |
GM22(11) | Leu 137 → Pro | 64 | 0.128 |
AL49(11) | ΔAla 15, 16, 17 | 64 | 0.128 |
AL55(11) | Mutation in the repressor binding site | 64 | 0.256 |
DNBR-Low1 | ΔAla 18 – Ala 108 | 32 | 0.064 |
DNBR-Low2 | Thr51Aspfs*46 | 16 | 0.064 |
DNBR-Low3 | Gln 61 → Stop | 32 | 0.064 |