Table 3. Interaction between APOE genotype and fitness in determining BMI.

			BMI (kg/m2)
Fitness	APOE	n	Mean (SD)	Mean difference (95% CI)*	P value
High	Not E4-containing	104	16.39 (1.69)
	E4-containing	34	16.44 (1.68)	0.074 (-0.59, 0.73)	0.825
Low	Not E4-containing	104	18.07 (2.88)
	E4-containing	41	16.25 (1.65)	-1.78 (-2.74, -0.83)	<0.001
Difference in effect †					0.002

Fitness measured by shuttle test and dichotomised at the median.

*Linear regression adjusted for age and sex.

^†Difference in the association between E4 and BMI by fitness category.