Figure 3. Forest plot of the effect of the interaction between the FTO rs9939609 SNP and physical activity on BMI in a random effects meta-analysis of 19,268 children and adolescents.

The studies are sorted by sample size (largest sample size lowest). Details of the studies are given in Text S1. The interaction Z-score represents the difference in age- and sex-standardized BMI per minor (A−) allele of rs9939609 comparing physically active children to inactive children. For example, a beta_interaction of −0.1 represents a 0.1 unit attenuation in the BMI Z-score-increasing effect of the rs9939609 minor allele in physically active children compared to inactive children.