Table 1. Association of the minor (A−) allele of the rs9939609 SNP or a proxy (r ²>0.8) in the FTO gene with BMI, waist circumference, body fat percentage, risk of obesity, and risk of overweight in a random effects meta-analysis of up to 218,166 adults.

Trait	Geographic Region	N	Beta or OR1 (95% CI)	p-Value	I 2
BMI (kg/m2)	All individuals	218,166	0.36 (0.32, 0.40)	1.8×10−75	34%
	Europe	164,307	0.32 (0.29, 0.34)	7.6×10−110	0%
	North America	47,938	0.42 (0.32, 0.53)	1.4×10−15	31%
	Asia	5,921	0.59 (0.33, 0.85)	7.9×10−6	39%
Waist circumference (cm)	All individuals	159,848	0.77 (0.66, 0.87)	5.4×10−43	28%
	Europe	128,811	0.71 (0.60, 0.82)	3.4×10−37	20%
	North America	25,117	0.89 (0.60, 1.17)	7.5×10−10	17%
	Asia	5,920	1.28 (0.69, 1.86)	1.8×10−5	34%
Body fat percentage (%)	All individuals	61,509	0.30 (0.24, 0.36)	2.2×10−21	1%
	Europe	60,617	0.29 (0.23, 0.36)	2.6×10−21	0%
	North America	892	0.79 (0.12, 1.47)	0.021	0%
	Asia	NA	NA	NA	NA
Risk of obesity (BMI ≥30 versus BMI <25 kg/m2)	All individuals	131,474	1.23 (1.20, 1.26)	7.2×10−59	28%
	Europe	97,877	1.22 (1.19, 1.25)	1.7×10−47	21%
	North America	29,282	1.26 (1.19, 1.33)	3.3×10−14	33%
	Asia	4,315	1.48 (1.25, 1.75)	4.8×10−6	0%
Risk of overweight (BMI ≥25 versus BMI <25 kg/m2)	All individuals	213,564	1.15 (1.13, 1.16)	5.5×10−66	10%
	Europe	163,069	1.14 (1.12, 1.16)	5.6×10−55	5%
	North America	44,574	1.14 (1.09, 1.18)	2.4×10−10	21%
	Asia	5,921	1.26 (1.14, 1.40)	4.9×10−6	0%

All models are adjusted for age and sex. Beta is the increase in trait per minor (A−) allele of rs9939609 or a proxy (r ²>0.8); I ² is the heterogeneity between studies in the association of rs9939609 with the trait.

¹Values are beta for all rows except risk of obesity and risk of overweight, for which values are OR.

NA, no data available for analysis.