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. 2011 Nov 1;8(11):e1001116. doi: 10.1371/journal.pmed.1001116

Table 2. Effect of the interaction between the rs9939609 SNP or a proxy (r 2>0.8) and PA on BMI, waist circumference, body fat percentage, risk of obesity, and risk of overweight in a random effects meta-analysis of up to 218,166 adults.

Trait Geographic Region Main Effect of rs9939609 in Inactive Individuals Main Effect of rs9939609 in Active Individuals Rs9939609×PA Interaction
N Beta or OR1 (95% CI) p-Value N Beta or OR1 (95% CI) p-Value N Betainteraction or Interaction OR1 (95% CI) p-Value I 2
BMI (kg/m2) All individuals 54,611 0.46 (0.37, 0.55) 3.7×10−23 163,555 0.32 (0.29, 0.36) 4.5×10−69 218,166 −0.14 (−0.23, −0.04) 0.0049 36%
Europe 44,052 0.37 (0.31, 0.44) 1.0×10−26 120,255 0.30 (0.27, 0.34) 2.4×10−62 164,307 −0.06 (−0.16, 0.03) 0.18 26%
North America 9,438 0.82 (0.65, 1.00) 2.7×10−21 38,500 0.34 (0.25, 0.44) 6.1×10−12 47,938 −0.49 (−0.65, −0.33) 1.6×10−9 0%
Asia 1,121 0.78 (0.14, 1.43) 0.017 4,800 0.53 (0.32, 0.75) 1.0×10−6 5,921 −0.37 (−0.86, 0.13) 0.15 0%
Waist circumference (cm) All individuals 38,560 1.01 (0.80, 1.22) 2.6×10−21 121,288 0.68 (0.58, 0.79) 9.2×10−35 159,848 −0.33 (−0.54, −0.12) 0.0018 5%
Europe 32,519 0.87 (0.65, 1.09) 1.2×10−14 96,292 0.65 (0.55, 0.75) 1.4×10−35 128,811 −0.22 (−0.44, 0.00) 0.049 4%
North America 4,921 1.72 (1.16, 2.28) 1.4×10−9 20,196 0.65 (0.30, 1.01) 3.2×10−4 25,117 −1.02 (−1.60, −0.45) 4.6×10−4 0%
Asia 1,120 1.65 (0.80, 1.22) 0.029 4,800 1.12 (0.61, 1.62) 1.5×10−5 5,920 −0.84 (−2.03, 0.35) 0.16 0%
Body fat percentage (%) All individuals 11,839 0.44 (0.30, 0.58) 1.0×101−9 49,670 0.28 (0.20, 0.37) 9.4×10−12 61,509 −0.19 (−0.35, −0.04) 0.016 0%
Europe 11,658 0.43 (0.29, 0.57) 3.1×10−9 48,959 0.29 (0.20, 0.38) 4.8×10−10 60,617 −0.18 (−0.34, −0.03) 0.023 0%
North America 181 2.03 (0.35, 3.70) 0.018 711 0.48 (−0.26, 1.22) 0.20 892 −1.57 (−3.34, 0.20) 0.082 0%
Asia NA NA NA NA NA NA NA NA NA NA
Risk of obesity (BMI ≥30 versus BMI <25 kg/m2) All individuals 32,774 1.30 (1.24, 1.36) 1.1×10−29 97,779 1.22 (1.19, 1.25) 1.0×10−46 131,474 0.92 (0.88, 0.97) 0.0010 5%
Europe 26,139 1.27 (1.22, 1.33) 2.9×10−29 71,738 1.21 (1.17, 1.25) 9.1×10−35 97,877 0.94 (0.90, 0.99) 0.028 0%
North America 5,777 1.43 (1.28, 1.60) 6.0×10−10 23,505 1.22 (1.15, 1.30) 1.0×10−9 29,282 0.85 (0.75, 0.98) 0.024 24%
Asia 858 1.86 (1.17, 2.93) 0.0082 3,457 1.41 (1.18, 1.70) 1.9×10−4 4,315 0.74 (0.46, 1.20) 0.23 0%
Risk of overweight (BMI ≥25 versus BMI <25 kg/m2) All individuals 53,726 1.19 (1.15, 1.23) 2.0×10−22 159,838 1.14 (1.12, 1.16) 2.1×10−42 213,564 0.95 (0.91, 0.99) 0.015 20%
Europe 43,833 1.17 (1.13, 1.20) 5.8×10−26 119,236 1.14 (1.11, 1.16) 3.2×10−29 163,069 0.96 (0.92, 1.01) 0.090 14%
North America 8,772 1.24 (1.11, 1.39) 1.8×10−4 35,802 1.13 (1.09, 1.17) 1.0×10−12 44,574 0.89 (0.80, 0.99) 0.034 21%
Asia 1,121 1.21 (0.79, 1.87) 0.38 4,800 1.26 (1.13, 1.41) 4.9×10−5 5,921 0.99 (0.67, 1.48) 0.98 50%

All models are adjusted for age and sex. Beta is the increase in trait per minor allele of rs9939609 or a proxy (r 2>0.8); betainteraction is the difference in trait per minor allele of rs9939069 comparing physically active individuals to inactive individuals, e.g., a betainteraction of −0.14 kg/m2 for BMI represents a 0.14 kg/m2 attenuation in the BMI-increasing effect of the rs9939609 minor allele in physically active individuals compared to inactive individuals; I 2 is the heterogeneity between studies in the meta-analysis; interaction OR is the ratio of ORs (OR[physically active]/OR[inactive]) per minor allele of rs9939609, e.g., an interaction OR of 0.92 for risk of obesity indicates that the obesity-increasing effect of the rs9939609 minor allele in physically active individuals is 0.92 of the effect in inactive individuals.

1

Values are beta/betainteraction for all rows except risk of obesity and risk of overweight, for which values are OR/interaction OR.

NA, no data available for analysis.