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. 2011 Nov 1;6(11):e26838. doi: 10.1371/journal.pone.0026838

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Sun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The response patterns to different ALT concentrations in C3^−/− and wt mice (n = 4–5). (B–D) The serum levels of proinflammatory cytokines after LPS/D-GalN injection. The concentrations of TNF-α and IL-6 in the C3^−/− mice were lower than in the wt C57BL/6 mice at 1 hour, but the levels of these cytokines in both groups decreased to the same concentrations at later time points. There was no difference in MCP-1 between the groups (n = 4–5). (E) The C3^−/− mice had prolonged life spans and an increased survival rate after LPS/D-GalN injection (n = 8). *** indicate p<0.001, in the comparison between the C3^−/− and C57BL/6 groups. The means±SEM are shown. The results are representative of 3 separate experiments.