Table 1. Secondary structure content for apoE3 and variants calculated from Circular Dichroism spectroscopy experiments.

apoE3	% α-helix222 nm 1	CDSSTR 2
		% Helix	% Strand	% Turns	% Unordered	NRMSD3
WT	58.7±3.2	62	15	10	13	0.004
R145C	56.8±1.2	59	16	11	14	0.005
K146E	59.7±2.2	61	16	10	12	0.004
R136S	59.4±4.9	60	16	11	14	0.004

¹Values are means ± SD from three to four experiments.

²prediction is averaged over sets 4,7 and SP175.

³parameter refers to quality of fit of modeled spectra to actual spectra, see reference [57].