Table 2. Parameters calculated for the thermal unfolding of apoE3 and variants.

apoE3	Tm (°C)	n1	apparent ΔΗ (kcal/mol)1
WT	53.6±0.2	7.7±0.2	27.9±0.1
R145C	53.4±0.3	6.9±0.4***	21.3±1.4****
K146E	55.7±0.1 *	7.9±0.2	27.3±1.1
R136S	51.9±0.4**	7.6±0.6	27.4±0.8

Values are means ± SD from three to four experiments.

*p = 0.002, ** p = 0.004, *** p = 0.015, **** p = 0.007.

1parameters calculated assuming a reversible two-state model.