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. 2011 Nov 1;6(11):e27063. doi: 10.1371/journal.pone.0027063

Figure 3. CD44 expression is increased in areas of invasion after E-cadherin loss.

Figure 3

Immunohistochemistry of paraffin sections with anti-E-cadherin antibody (A), anti-TGFβRII (B) and anti-CD44 (C) shows CD44–positive cells in EC and ECdnT cells invading into the underlying collagen/matrigel matrix (arrows) that are negative for E-cadherin and TGFβRII. Immunohistochemical staining for the EMT markers S100A4 (D), vimentin (E) and αSMA (F) shows increased positive signal in invading cells. Scale bar is 50 micron.