TABLE 1.

Clinical characteristics

	AN − E (n = 137)	AN + E (n = 32)	HA (n = 21)	HC (n = 27)
Age (yr)	25.4 ± 0.6	24.6 ± 1.0	24.2 ± 1.1	24.2 ± 0.6
BMI (kg/m2)	16.7 ± 0.1a	17.1 ± 0.2a	20.7 ± 0.3	21.0 ± 0.3
% BW	74.8 ± 0.5a	77.0 ± 1.2a	93.0 ± 1.4	94.4 ± 1.1
Total fat mass (kg)	7.8 ± 0.3a	8.9 ± 0.7a	14.4 ± 0.8	15.5 ± 0.6
% fat	17.3 ± 0.5a	18.2 ± 1.1a	26.1 ± 1.2	27.2 ± 0.7
Fat-free mass (kg)	35.4 ± 0.4a	37.2 ± 0.7b	38.8 ± 1.1	39.0 ± 0.8
PA spine BMD Z-score	−1.7 ± 0.1a	−1.4 ± 0.2a	−0.6 ± 0.2c	0.3 ± 0.2
Lateral spine BMD Z-score	−2.0 ± 0.1a	−1.5 ± 0.2b	−0.8 ± 0.2c	0.0 ± 0.2
Hip BMD Z-score	−1.5 ± 0.1a	−0.9 ± 0.2b	−0.3 ± 0.3	0.1 ± 0.2
Radius BMD Z-score	−0.7 ± 0.1a	−1.0 ± 0.2a	0.6 ± 0.2	0.7 ± 0.2
Total-body BMD Z-score	−1.3 ± 0.1a	−0.9 ± 0.2a	0.4 ± 0.2	0.7 ± 0.2
Duration of amenorrhea (months)	25.1 ± 3.1a	NA	10.9 ± 2.1	0.0 ± 0.0

Data are reported as mean ± SEM. There was no difference between the AN − E and AN + E groups in BMD at any site after controlling for percent IBW. AN − E, Women with anorexia nervosa not receiving oral contraceptives; AN + E, women with anorexia nervosa receiving oral contraceptives; HA, normal-weight women with hypothalamic amenorrhea; HC, healthy controls of reproductive age; NA, not applicable.

^aP < 0.05 compared with HC and HA.

^bP < 0.05 compared with AN − E, HC, and HA.

^cP < 0.05 compared with HC only.