Table 2.
Health screening results according to CAD status
| No CAD (N=65,044) | CAD (no revascularization) (N=3406) | Any revascularization (PCI or CABG) (N=2004) | Total (N=70,454) | P valuea | |
|---|---|---|---|---|---|
| N (%) | N (%) | N (%) | N (%) | ||
| Body mass index (kg/m2) (missing=1180) | 30.1±6.8 | 30.8±6.8 | 30.1±6.2 | 30.2±6.8 | <0.0001 |
| Diabetic (reported DM or glucose >125 [6.9 mmol/L] if fasting, else >200 mg/dL [11.1 mmol/L]) (missing=18) | 17,005 (26.2) | 1653 (48.5) | 1019 (50.9) | 19,677 (27.9) | <0.0001 |
| Using insulin (KEEP question 7c) (missing=55,435) | 1058 (8.3) | 126 (14.1) | 270 (19.8) | 1454 (9.7) | <0.0001 |
| Plasma glucose (mean) for diabetics only in mg/dL [mmol/L] (n=19,243) | 158.9±81.1 [8.8±4.5] | 164.5±81.9 [9.2±4.6] | 154.2±71.6 [8.6±4.0] | 159.1±80.7 [8.8±4.5] | 0.0109 |
| N (%) glucose ≥125 mg/dL (6.9 mmol/L) (missing=1689) | 13,872 (21.9) | 1260 (37.9) | 722 (36.7) | 15,854 (23.1) | <0.0001 |
| Mean total cholesterol from central laboratory (n=26,293) | 201.1±41.0 | 197.9±45.0 | 182.6±43.6 | 199.6±41.6 | <0.0001 |
| N (%) with total cholesterol ≥200 mg/dL (5.2 mmol/L) (missing=44,161) | 11,219 (48.5) | 560 (45.3) | 589 (30.3) | 12,368 (47.0) | <0.0001 |
| Smoking (missing=4090) | <0.0001 | ||||
| Never smoked | 36,639 (59.8) | 1417 (44.3) | 894 (47.7) | 38,950 (58.7) | |
| Current smoker | 7464 (12.2) | 457 (14.3) | 193 (10.3) | 8114(12.2) | |
| Former smoker | 17,191 (28.1) | 1322 (41.4) | 787 (42.0) | 19,300 (29.1) | |
| Hypertensive (hypertension medications or SBP ≥140 or DBP ≥90 mm Hg) (missing=10) | 41,016(63.1) | 2874 (84.4) | 1721 (85.9) | 45,611 (64.8) | <0.0001 |
| N (%) with SBP ≥130 mm Hg (missing=938) | 35,727 (55.7) | 2194 (65.2) | 1263 (63.3) | 39,184 (56.4) | <0.0001 |
| Albumin:creatinine ≥30 mg/g (3.4 mg/mmol) (missing=9883) | 6257 (11.2) | 558 (19.2) | 359 (18.3) | 7174 (11.8) | <0.0001 |
| eGFR category (missing=3931) | <0.0001 | ||||
| eGFR <30 mL/min/1.73 m2 | 473 (0.8) | 84 (2.6) | 54 (2.8) | 611 (0.9) | |
| eGFR 30–59 mL/min/1.73 m2 | 9149 (14.9) | 932 (29.1) | 579 (30.5) | 10,660 (16.0) | |
| eGFR 60–89 mL/min/1.73 m2 | 31,421 (51.2) | 1553 (48.5) | 962 (50.7) | 33,936 (51.0) | |
| eGFR ≥90 mL/min/1.73 m2 | 20,382 (33.2) | 630 (19.7) | 304 (16.0) | 21,316 (32.0) | |
| eGFR <60 mL/min/1.73 m2 (missing=3931) | 9622 (15.7) | 1016 (31.8) | 633 (33.3) | 11,271 (16.9) | <0.0001 |
| Under care of cardiologist (KEEP question 24) | 1758 (2.7) | 293 (8.6) | 1103 (55.0) | 3154 (4.5) | <0.0001 |
| Under care of nephrologist (KEEP question 24) | 882 (1.4) | 83 (2.4) | 118 (5.9) | 1083 (1.5) | <0.0001 |
| Neither cardiologist nor nephrologist | 62,525 (96.1) | 3054 (89.7) | 875 (43.7) | 66,454 (94.3) | <0.0001 |
CABG coronary artery bypass graft surgery; CAD coronary artery disease; DBP diastolic blood pressure; DM diabetes mellitus; eGFR estimated glomerular filtration rate; HTN hypertension; KEEP Kidney Early Evaluation Program; PCI percutaneous coronary intervention; SBP systolic blood pressure
a
P value for comparing no CAD, CAD without revascularization, prior PCI, prior CABG, and both PCI and CABG
(Adapted from McCullough et al. [11•])