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A subsarcolemmal (SSM) mitochondriocentric signal-transducer-effector pathway to cardiomyocyte necrosis evoked by either catecholamines or parathyroid hormone (PTH). [Ca2+]i Intracellular calcium; [Ca2+]m Mitochondrial-free calcium concentration; [Ca2+]o Extracellular calcium; mPTP Mitochondrial permeability transition pore. Adapted from reference 118
