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. 2011 Winter;16(4):109–115.

Figure 3).

Figure 3)

Homeostasis gone awry begets dyshomeostasis leading to cardiomyocyte necrosis and myocardial fibrosis. [Ca2+]i Intracellular calcium; [Ca2+]o Extracellular calcium; CypD Cyclophilin D; mPTP Mitochondrial permeability transition pore; PTH Parathyroid hormone; RAAS Renin-angiotensin-aldosterone system; RBF Renal blood flow; RNS Reactive nitrogen species; ROS Reactive oxygen species; SHPT Secondary hyperparathyroidism. Reproduced with permission from reference 119