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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: J Crit Care. 2011 Jul 27;27(3):314.e1–314.e11. doi: 10.1016/j.jcrc.2011.05.025

Figure 2. Sepsis: A process flow.

Figure 2

Figure 2

Upon stimulation by pathogens, a multifaceted inflammatory response ensues, driven by cytokines, free radical reaction products, and damage-associated molecular patterns (DAMPs). Panel A: The inflammatory response affects, and is affected by, interactions with physiological systems (manifest as reduced physiological variability) and the coagulation and complement cascades. Panel B: The acute inflammatory response is sensed via defined receptors for both pathogen-derived products and DAMPs, and modulated via intracellular signaling pathways.