Table 3.
Relative risk of CHD during 14 years of follow-up according to baseline plasma levels of total or HMW adiponectin or HMW/total adiponectin ratio
| Quintile |
Continuously (per doubling) |
||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | p trend* | ||
| Total adiponectin | |||||||
| Median (range), mg/L† | 4.83 (1.57-5.97) | 6.99 (5.97-7.88) | 8.67 (7.89-9.53) | 10.81 (9.54-12.37) | 14.69 (12.39-28.45) | ||
| Cases, no. | 153 | 96 | 67 | 84 | 55 | ||
| Controls, no. | 182 | 182 | 182 | 182 | 183 | ||
| Relative risk (95%-CI) | |||||||
| Adjusted for matching factors‡ | 1 | 0.62 (0.45-0.87) | 0.43 (0.30-0.61) | 0.52 (0.37-0.73) | 0.35 (0.24-0.51) | <0.0001 | 0.57 (0.47-0.68) |
| Multivariable adjusted§ | 1 | 0.80 (0.56-1.14) | 0.53 (0.36-1.78) | 0.76 (0.52-1.12) | 0.50 (0.33-0.75) | 0.001 | 0.70 (0.57-0.85) |
| HMW adiponectin | |||||||
| Median (range), mg/L† | 2.21 (0.46-3.00) | 3.75 (3.01-4.32) | 5.03 (4.33-5.79) | 6.65 (5.79-7.95) | 9.83 (7.96-23.87) | ||
| Cases, no. | 152 | 88 | 83 | 76 | 56 | ||
| Controls, no. | 182 | 182 | 182 | 182 | 183 | ||
| Relative risk (95%-CI) | |||||||
| Adjusted for matching factors‡ | 1 | 0.57 (0.41-0.80) | 0.53 (0.38-0.75) | 0.48 (0.33-0.67) | 0.35 (0.24-0.51) | <0.0001 | 0.67 (0.59-0.76) |
| Multivariable adjusted§ | 1 | 0.77 (0.54-1.11) | 0.69 (0.48-1.00) | 0.71 (0.48-1.05) | 0.53 (0.35-0.80) | 0.004 | 0.78 (0.67-0.90) |
| HMW/total adiponectin ratio | |||||||
| Median (range)† | 0.44 (0.10-0.49) | 0.52 (0.49-0.55) | 0.58 (0.55-0.60) | 0.63 (0.60-0.66) | 0.71 (0.67-0.93) | ||
| Cases, no. | 151 | 76 | 75 | 85 | 68 | ||
| Controls, no. | 182 | 181 | 182 | 182 | 183 | ||
| Relative risk (95%-CI) | |||||||
| Adjusted for matching factors‡ | 1 | 0.50 (0.36-0.71) | 0.48 (0.34-0.68) | 0.55 (0.39-0.77) | 0.44 (0.31-0.62) | <0.0001 | 0.41 (0.29-0.59) |
| Multivariable adjusted§ | 1 | 0.62 (0.43-0.90) | 0.63 (0.43-0.91) | 0.73 (0.51-1.06) | 0.63 (0.43-0.93) | 0.03 | 0.63 (0.43-0.92) |
*
P values for trend are based on the median plasma levels in quintiles of the controls.
†
Quintiles, medians, and ranges are based on controls only.
‡
Adjusted for matching factors, including age, smoking status, date of blood draw, fasting status, and reported problems with blood draw
§
Multivariable models are adjusted for matching factors, parental history of myocardial infarction, hormone replacement therapy use, alcohol consumption, physical activity, BMI, history of hypertension, and LDL-C levels