Fig 3.
Mean densities (error bars indicate standard errors) of the vacuolation, surviving neurons, and enlarged neurons (EN) in the frontal and temporal lobe (MFG = Middle frontal gyrus, ITG = Inferior temporal gyrus, PHG = Parahippocampal gyrus, CA1/2 = Sectors CA/2 of the hippocampus, DG = Dentate gyrus), U = Upper cortex, L = lower cortex) of cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP). Analysis of variance (1-way): 1) Comparing upper cortex, CA1/2, and DG data, Vacuoles F = 8.34 (P < 0.001), Surviving neurons = 131.97 (P < 0.001), EN F = 7.18 (P < 0.001); 2) Comparing lower cortex, CA1/2, DG data: Vacuoles F = 2.95 (P < 0.05), Surviving neurons F = 166.89 (P < 0.001), EN F =10.52 (P < 0.001).