Table 7.
Comparison of the densities (per 50 × 250µm field, standard errors in parentheses) of the pathological changes (NCI = neuronal cytoplasmic inclusions, NII = neuronal intranuclear inclusions, SN = surviving neurons, EN = abnormally enlarged neurons) between the four subtypes of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) based on the composite scheme of Cairns et al (2007b). Data show brain regions (MFG = Middle frontal gyrus, ITG = Inferior temporal gyrus, PHG = parahippocampal gyrus) and pathological features that exhibit a significant difference between groups.
| Subtype | ||||||
|---|---|---|---|---|---|---|
| Brain region |
Pathological feature |
1 | 2 | 3 | 4 | |
| MFG (upper cortex) |
NCI | 0.06 (0.04) | 0.37 (0.06) | 0.28 (0.08) | 0.15 (0.07) | |
| MFG (lower cortex) |
NII | 0.19 (0.06) | 0.18 (0.06) | 0.13 (0.06) | 0.39 (0.06) | |
| ITG (upper cortex) |
NCI | 0.08 (0.05) | 0.29 (0.05) | 0.28 (0.06) | 0.10 (0.05) | |
| NII | 0.04 (0.02) | 0.08 (0.03) | 0.09 (0.06) | 0.32 (0.07) | ||
| SN | 5.03 (0.71) | 6.45 (0.73) | 7.82 (0.93) | 3.67 (0.71) | ||
| Vacuoles | 10.53 (1.24) | 8.46 (1.24) | 10.11 (1.57) | 5.30 (1.24) | ||
| ITG (lower Cortex |
NCI | 0.06 (0.03) | 0.31 (0.05) | 0.02 (0.01) | 0.04 (0.02) | |
| Vacuoles | 10.26 (0.70) | 2.30 (0.69) | 6.21 (0.77) | 5.45 (0.69) | ||
| PHG (upper cortex) |
Vacuoles | 16.31 (1.78) | 6.36 (1.75) | 10.34 (2.27) | 6.81 (1.80) | |
| PHG (lower cortex) |
NII | 0.05 (0.03) | 0.20 (0.06) | 0.26 (0.08) | 0.42 (0.06) | |
| Sectors CA1/2 | EN | 0.15 (0.04) | 0.05 (0.04) | 0.22 (0.04) | 0.07 (0.04) | |
ANOVA (1-way): MFG-upper, NCI: F = 3.35 (P < 0.05) Subtype 2 > 1 and 2 > 4; MFG-lower NII F = 3.40 (P < 0.05), Subtype 4 >1,2,3; ITG-U, NCI: F = 4.51 (P < 0.05), Subtype 2,3 > 1,4; NII F = 3.53 (P < 0.05), Subtype 4 >1,2,3; SN F = 4.35 ( P < 0.05), Subtype 2,3 > 1,4; Vacuoles F = 3.46 (P< 0.05), Subtype 1,3 > 4; ITG-lower NCI F = 7.21 (P < 0.01), subtype 2 > 1,3,4; Vacuoles F = 5.46 (P < 0.01), Subtype 1 > 2,4; PHG-upper Vacuoles F = 5.01 (P < 0.01), Subtype 1 > 2,4; PHG-lower NII F = 5.57 (P < 0.01), Subtype 4 > 1,2; CA1/2 EN F = 3.77 (P < 0.05), Subtype 3 > 2,4.