Skip to main content
. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Cancer Res. 2011 Sep 15;71(21):6654–6664. doi: 10.1158/0008-5472.CAN-11-1446

Fig.1. Functional cooperation between E2-ERα and SIRT1.

Fig.1

(A) Expression of ERα and SIRT1 mRNAs in ER-positive (ER+) breast tumors tissues and adjacent normal tissues as well as in ER-negative (ER−) breast tumor tissues and corresponding normal tissues. (B) ERα and SIRT1 mRNA levels were quantified by densitometry. ** p<0.01. (C) SIRT1 mRNA expression in human normal, ER+ and ER− breast cancer cell lines. (D) SIRT1 mRNA expression in ZR75.1 cells, treated with or without E2 alone or in combination with TAM and ICI182740. (E) ERα and SIRT1 mRNA levels in ZR75.1 cells, cultured for several passages in regular and E2-free medium.