The relative expression level for TNF-α, IL6, IFN-γ, IL4, and IL13 mRNAs at 2 weeks, 8 weeks, 6 months and 12 months. Labels for X axis: “A” for aqueous and “H” for HFIP. For examples, “A 6% 500–600” represents aqueous-derived scaffolds with 500–600 µm pore size prepared from 6 % silk fibroin solution, while “H 6% 500–600” represents HFIP-derived scaffolds with 500–600 µm pore size prepared from 6 % silk fibroin solution. Y axis = relative expression level normalized to GAPDH. The missing bars in the graphs at varying timepoints indicate relative expression levels were not detectable.