Figure 1.

SCI mice retained their weight throughout the experiment. WT and tPA KO mice underwent sham or contusion injury and a single injection of Pen, ChABC, Pen+plasmin, or ChABC+plasmin on day 14. The weight was measured on the designated days and data were normalized to intact weight of the individual mouse of the respective genotype. Two-way group comparisons are presented in a–d. a and b compare differences due to genotype and time, while c and d illustrate differences due to treatment and time. e, Weight differences due to genotype and treatment were compared on day 21. Biological replicates are indicated in Table 1 under behavioral experiment.