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. 2011 Nov;138(5):521–535. doi: 10.1085/jgp.201110677

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© 2011 Nakajo et al.

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Figure 9. — Phenylalanine residues on the S1 segment of KCNQ1 play a role in KCNE3 modulation. (A) Location of phenylalanine residues on the hKCNQ1 S1 segment. Trp120 is not on the S1 segment and therefore is not depicted. (B) G-V relationships for hQ1 F(W)-to-A mutants in the absence (left) and presence of KCNE3 (right). All but WT KCNQ1, W120A, and F123A with KCNE3 are fitted with the Boltzmann equation. For the WT KCNQ1, W120A, and F123A with KCNE3, plots were connected by dotted lines, as they could not be fitted with the Boltzmann equation.