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FABP4 bound with a fatty acid or a small molecule inhibitor. (a) Human FABP4 binds to an endogenous fatty acid, palmitic acid, as a twisted U-shaped entity in the binding pocket (PDB code: 2hnx). (b) Human FABP4 crystallized in complex with BMS309403, a synthetic FABP4 inhibitor, is shown (PDB code: 2nnq). The molecule occupies the internal binding pocket of FABP4 and competitively inhibits binding of endogenous fatty acids. The figures were created using PyMOL.
