Table 3.

Risk stratification for high-risk prostate cancer.

Source	High-risk definition
D'Amico et al. [13]	Stage T2c or PSA > 20 ng/mL or Gleason > 8
RTOG 9902, 0521 [14, 15]	Any T stage, PSA 20–100 ng/mL, Gleason > 7 or stage ≥ T2, PSA < 100 ng/mL, Gleason 8–10
NCCN (v1.2011) [16]	Stage ≥ T3 and/or PSA > 20 ng/mL and/or Gleason 8–10*

Adapted from Nat Rev Urol 2010 Nature Publishing Group [17]. *Combines high-risk and very high risk (locally advanced) groups.